GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2130392 | 1 | rs4862406 | chr4:185629339 | CCDC111 | chr4:185570767-185616112:+ | -0.34 | -4.24 | 5.14E-5 | Kawasaki disease |
| THYM | cis | rs2130392 | 1 | rs4862406 | chr4:185629339 | MLF1IP | chr4:185615220-185655286:- | 0.33 | 7.26 | 1.08E-10 | Kawasaki disease |
| THYM | cis | rs2251844 | 1 | rs486301 | chr15:43836949 | ADAL | chr15:43622872-43646094:+ | -0.62 | -5.23 | 1.01E-6 | Tumor biomarkers |
| THYM | cis | rs4869313 | 1 | rs4869313 | chr5:96223880 | ERAP2 | chr5:96211644-96255398:+ | -1.01 | -20.41 | 1.67E-36 | Pediatric autoimmune diseases |
| THYM | cis | rs11148252 | 1 | rs4886018 | chr13:52990717 | CKAP2 | chr13:53029495-53050763:+ | -0.35 | -5.4 | 4.97E-7 | Lewy body disease |
| THYM | cis | rs936229 | 1 | rs4886615 | chr15:75131661 | ULK3 | chr15:75128459-75135552:- | -0.42 | -5.18 | 1.25E-6 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THYM | cis | rs4888262 | 1 | rs4887783 | chr16:74700743 | RFWD3 | chr16:74655298-74700779:- | -0.23 | -5.03 | 2.28E-6 | Testicular germ cell tumor |
| THYM | cis | rs4888262 | 1 | rs4888262 | chr16:74670458 | RFWD3 | chr16:74655298-74700779:- | -0.23 | -5.04 | 2.24E-6 | Testicular germ cell tumor |
| THYM | cis | rs4888262 | 1 | rs4888264 | chr16:74681632 | RFWD3 | chr16:74655298-74700779:- | -0.21 | -4.54 | 1.68E-5 | Testicular germ cell tumor |
| THYM | cis | rs4888262 | 1 | rs4888265 | chr16:74683737 | RFWD3 | chr16:74655298-74700779:- | -0.21 | -4.54 | 1.64E-5 | Testicular germ cell tumor |
| THYM | cis | rs2239557 | 1 | rs4903201 | chr14:74659690 | LIN52 | chr14:74551656-74667117:+ | -0.39 | -7.22 | 1.25E-10 | Common traits (Other) |
| THYM | cis | rs2239557 | 1 | rs4903202 | chr14:74660302 | LIN52 | chr14:74551656-74667117:+ | -0.39 | -7.22 | 1.25E-10 | Common traits (Other) |
| THYM | cis | rs2239557 | 1 | rs4903203 | chr14:74660508 | LIN52 | chr14:74551656-74667117:+ | -0.39 | -7.22 | 1.25E-10 | Common traits (Other) |
| THYM | cis | rs975752 | 1 | rs4919429 | chr10:101938630 | BLOC1S2 | chr10:102033713-102046439:- | -0.52 | -5.18 | 1.27E-6 | Schizophrenia |
| THYM | cis | rs975752 | 1 | rs4919431 | chr10:101944325 | BLOC1S2 | chr10:102033713-102046439:- | -0.49 | -5.28 | 8.32E-7 | Schizophrenia |